I've been riding a 42.5 mm stroke shock on my size L frame since March. Plenty of clearance with the shock bottomed out, never had any contact between the seat stay brace and seat tube. Not even any semblance of worry that it might happen, because it won't.
And yes, I have bottomed. I jump the thing, come off drops, ride it like a MTB should be ridden, not just on some lame gravel trails.
I ride cross country trails, flow trails, trails with natural technical rocks, roots, drops, jumps terrain, sanitized bike park trails with manufactured jumps and drops. I'll take the natural terrain trails all day every day over manufactured bike park stuff.
And I'm 225 lbs.
But sure, you guys keep on going on about your hypotheticals. In the real world, the 42.5 mm stroke works beautifully with the frame.