The Lefty on my 256 is 10mm off from the AC distance defined on the geometry.
Making it in theory steeper than it should.
I'm still not convinced of the effects of small variations in the chainstay, the offset of the fork, the angle of the head tube/seat tube, etc.
Even if Cannondale market all this massively on their FSi for instance.
However if a brake lever is just few mm lower on one side, the seat is a hair lower, etc. after a fall for instance, I notice it immediately.
Like if someone change, even slightly, the position of your car seat or driving wheel.
So small things matter apparently.
The problem, is that it's very difficult to isolate a change like the head tube angle and be sure of its effect.
Testing the same bike with different fork length could be a good test, even if the whole frame angle change.