I wouldn't see why not. If the course is bumpy and rough, has some nice downhill sections, has loose gravel, or is muddy, a plus tire will have an advantage. However, if there is a lot of uphill and the trail is smooth, a lightweight XC bike will have an advantage. For the trails I ride, I have timed myself and confirmed I am faster on the Stache 29+ and on my Spec SJ6F 27.5+ all with more confidence and more fun.