i'm running 50-34 and 11-42 on my GRX 400 and a clutch in on makes a hugh differnce in chaining up gears from the middle of the cassette. But as the RD moves a lot further away to compensate for the 42 dinner plate in the back, at least for me the switched on clutch is no longer needed on gravel stuff.
so if the EGR has a clutch switch, the off position should work fine.
