Same issue here, the big bolt always gets loose over time, left crank arm then travels outwards.
Luckily i always recognized it in time before anything separated
Tried to fix it several times, checked torque, cleaned everything, used thread locker, without any success.
Thought this might happen to me since i use it out of spec, - on a gravel bike with GRX setup. In Order to get the front derallieur working, maintain a functional chainline and keep everything symmetrical, i used 2mm spacers on each side of the BB, resulting in 4mm less "clamping surface" for the left crank arm.
After reading several reports here, it seems thats not what causes the issues.
Hope i can find some time to dig a bit deeper into this issue soon an will report here in case of any interesting findings...